SKRIPSI
Formulasi Dan Uji Aktivitas Krim Tea Tree Oil ( Melaleuca alternifolia ) Terhadap Bakteri Staphylococcus epidermidis
Telah dilakukan formulasi krim tea tree oil dan uji aktivitas antibakteri terhadap bakteri Staphylococcus epidermidis. Penelitian ini bertujuan untuk melihat aktivitas antibakteri tea tree oil setelah diformulasi dalam bentuk krim dengan berbagai konsentrasi. Konsentrasi tea tree oil yang digunakan adalah 3%, 5% dan 7%. Evaluasi sediaan krim dilakukan terhadap organoleptis, pH, homogenitas, stabilitas fisik, daya tercuci, daya menyebar dan uji iritasi serta uji daya aktivitas antibakteri terhadap bakteri Staphylococcus epidermidis menggunakan metode difusi. Hasil evaluasi krim menunjukkan bahwa semua formula krim memenuhi persyaratan. Formula III dengan konsentrasi tea tree oil 7% dapat menghambat pertumbuhan bakteri Staphylococcus epidermidis dengan kategori sedang berdiameter 9,96 mm. Research have done a cream formulation and testing of tea tree oil Staphylococcus epidermidis antibacterial activity. The aim of this research to determine the antibacterial activity of tea tree oil after becoming cream formulated with various concentrations. The concentration of tea tree oil that used on cream was 3%, 5% and 7%. The cream evaluation consist of organoleptic, pH, homogeneity, physical stability, washability, spreadability and irritation test and antibacterial activity was tested using diffusion method. The evaluation results showed that all the cream formulas meet the requirements. The antibacterial test showed that the cream containing 7% tea tree oil inhibited the growth of bacterial Staphylococcus epidermidis with medium category that a diameter of 9,96 mm.
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