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Dictionary of Nutraceuticals and Functional Foods
Acacia gum
Acacia gums, or gum arable, are Acacia-tree exudates that are highly branched galactan
polymers with galactose or arabinose side chains terminated by rhamnose or glucuronic
acid. It cannot be digested in the small intestine but behaves as a prebiotic by enhancing
the growth of the probiotic bifidobacteria (Wyatt et al., 1986; Crociani et al., 1994).
Michel and coworkers (1998) confirmed the similarity between two acacia gums and a
prebiotic fructooligosaccharide with respect to their ability to decrease Clostridium sp.
levels in human intestinal microbiota, as well as increase Lactobacillus sp. counts.
However, the fructooligosaccharide preparation induced higher levels of Lactobacillu sp.
The overall effect was attributed to increased production of short-chain fatty acids.
Hosobuchi et al. (1999) demonstrated the efficacy of supplementing diets with acacia
gum, pectin, and guar gum for controlling hypercholesterolemia. A significant reduction
was observed for both total and LDL cholesterol in 50 adults after four weeks on the
supplemented diet.
Arabic gum was shown by Rehman et al. (2001) to scavenge nitric oxide. The
decrease in the production of nitric oxide by arabic gum was later shown by Gamal eladin et al. (2003) to protect against acetaminophen-induced hepatoxicity in mice. This
reduction in oxidative stress (nitric-oxide production) was similar to the protection by
arabic gum against gentamycin-induced nephrotoxicity reported previously by Al-Majed
et al. (2002).
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